ACE2 & TMPRSS2 Expressions in Head & Neck Tissues: A Systematic Review.
Identifieur interne : 001794 ( Main/Exploration ); précédent : 001793; suivant : 001795ACE2 & TMPRSS2 Expressions in Head & Neck Tissues: A Systematic Review.
Auteurs : Jerome R. Lechien [France, Belgique] ; Thomas Radulesco [France] ; Christian Calvo-Henriquez [France, Espagne] ; Carlos M. Chiesa-Estomba [France, Espagne] ; Stéphane Hans [France] ; Maria R. Barillari [France, Italie] ; Giovanni Cammaroto [France, Italie] ; Géraldine Descamps [France, Belgique] ; Julien Hsieh [France, Suisse] ; Luigi Vaira [France, Italie] ; Giacomo De Riu [France, Italie] ; Leigh Sowerby [France, Canada] ; Isabelle Gengler [France, États-Unis] ; Justin Michel [France] ; Sven Saussez [France, Belgique]Source :
- Head and neck pathology [ 1936-0568 ] ; 2020.
Abstract
To review the data regarding the expression of angiotensin converting enzyme-2 (ACE2) and transmembrane protease serine-2 (TMPRSS2) in head and neck tissue. Scopus, Cochrane Library, Medrxiv, Google Scholar and PubMED/MEDLINE were searched by four independent investigators for studies investigating ACE2 or TMPRSS2 expressions in head and neck tissues. The following outcomes were considered: sample origin (animal versus human); detection method; anatomical location and cell types. PRISMA checklist and modified population, intervention, comparison, outcome, timing and setting (PICOTS) framework were used to perform the review. Of the 24 identified studies, 17 met our inclusion criteria. Thirteen studies were conducted during the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic. ACE2 and TMPRSS2 were expressed in oral, pharyngeal, sinusonasal human mucosa. The following cell types expressed ACE2: basal, apical, goblet, minor salivary, and endothelial cells. TMPRSS2 was found in goblet and apical respiratory cells. ACE2 and TMPRSS2 were found in the olfactory region, especially in sustentacular non-neural and neural stem cells. Animal studies suggested that ACE2 expression may vary regarding age. There was an important heterogeneity between studies in the methods used to detect ACE2 and TMPRSS2, leading to a potential identification bias. The SARS-CoV-2 receptors, ACE2 and TMPRSS2, are both expressed in many head and neck tissues, enabling the viral entry into the host organism.
DOI: 10.1007/s12105-020-01212-5
PubMed: 32816230
PubMed Central: PMC7439628
Affiliations:
- Belgique, Canada, Espagne, France, Italie, Suisse, États-Unis
- Ohio, Provence-Alpes-Côte d'Azur, Province de Hainaut, Région de Bruxelles-Capitale, Région wallonne, Île-de-France
- Bruxelles, Liège, Marseille, Paris
- Université de Mons, Université libre de Bruxelles
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Lechien</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France. jerome.lechien@umons.ac.be.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium. jerome.lechien@umons.ac.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Human Anatomy and 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Radulesco</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception University Hospital, Aix Marseille Univ, APHM, IUSTI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception University Hospital, Aix Marseille Univ, APHM, IUSTI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Calvo Henriquez, Christian" sort="Calvo Henriquez, Christian" uniqKey="Calvo Henriquez C" first="Christian" last="Calvo-Henriquez">Christian Calvo-Henriquez</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology-Hospital Complex of Santiago de Compostela, Santiago de Compostela, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Otolaryngology-Hospital Complex of Santiago de Compostela, Santiago de Compostela</wicri:regionArea><wicri:noRegion>Santiago de Compostela</wicri:noRegion></affiliation></author><author><name sortKey="Chiesa Estomba, Carlos M" sort="Chiesa Estomba, Carlos M" uniqKey="Chiesa Estomba C" first="Carlos M" last="Chiesa-Estomba">Carlos M. Chiesa-Estomba</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology-Head & Neck Surgery, Hospital Universitario Donostia, San Sebastian, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Otorhinolaryngology-Head & Neck Surgery, Hospital Universitario Donostia, San Sebastian</wicri:regionArea><wicri:noRegion>San Sebastian</wicri:noRegion></affiliation></author><author><name sortKey="Hans, Stephane" sort="Hans, Stephane" uniqKey="Hans S" first="Stéphane" last="Hans">Stéphane Hans</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Foch Hospital, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Foch Hospital, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Barillari, Maria R" sort="Barillari, Maria R" uniqKey="Barillari M" first="Maria R" last="Barillari">Maria R. Barillari</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Mental and Physical Health and Preventive Medicine, University of L. Vanvitelli, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Mental and Physical Health and Preventive Medicine, University of L. Vanvitelli, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Cammaroto, Giovanni" sort="Cammaroto, Giovanni" uniqKey="Cammaroto G" first="Giovanni" last="Cammaroto">Giovanni Cammaroto</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology-Head & Neck Surgery, Morgagni Pierantoni Hospital, Forli, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Otolaryngology-Head & Neck Surgery, Morgagni Pierantoni Hospital, Forli</wicri:regionArea><wicri:noRegion>Forli</wicri:noRegion></affiliation></author><author><name sortKey="Descamps, Geraldine" sort="Descamps, Geraldine" uniqKey="Descamps G" first="Géraldine" last="Descamps">Géraldine Descamps</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons</wicri:regionArea><orgName type="university">Université de Mons</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Hainaut</region></placeName></affiliation></author><author><name sortKey="Hsieh, Julien" sort="Hsieh, Julien" uniqKey="Hsieh J" first="Julien" last="Hsieh">Julien Hsieh</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Rhinology-Olfactology Unit, Department of Otorhinolaryngology, Head and Neck Surgery, Geneva University Hospitals (HUG), Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Rhinology-Olfactology Unit, Department of Otorhinolaryngology, Head and Neck Surgery, Geneva University Hospitals (HUG), Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Vaira, Luigi" sort="Vaira, Luigi" uniqKey="Vaira L" first="Luigi" last="Vaira">Luigi Vaira</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Maxillofacial Surgery Unit, University Hospital of Sassari, Sassari, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Maxillofacial Surgery Unit, University Hospital of Sassari, Sassari</wicri:regionArea><wicri:noRegion>Sassari</wicri:noRegion></affiliation></author><author><name sortKey="De Riu, Giacomo" sort="De Riu, Giacomo" uniqKey="De Riu G" first="Giacomo" last="De Riu">Giacomo De Riu</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Maxillofacial Surgery Unit, University Hospital of Sassari, Sassari, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Maxillofacial Surgery Unit, University Hospital of Sassari, Sassari</wicri:regionArea><wicri:noRegion>Sassari</wicri:noRegion></affiliation></author><author><name sortKey="Sowerby, Leigh" sort="Sowerby, Leigh" uniqKey="Sowerby L" first="Leigh" last="Sowerby">Leigh Sowerby</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Gengler, Isabelle" sort="Gengler, Isabelle" uniqKey="Gengler I" first="Isabelle" last="Gengler">Isabelle Gengler</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati Medical Center, Cincinnati, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati Medical Center, Cincinnati, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Michel, Justin" sort="Michel, Justin" uniqKey="Michel J" first="Justin" last="Michel">Justin Michel</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception University Hospital, Aix Marseille Univ, APHM, IUSTI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception University Hospital, Aix Marseille Univ, APHM, IUSTI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Saussez, Sven" sort="Saussez, Sven" uniqKey="Saussez S" first="Sven" last="Saussez">Sven Saussez</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons</wicri:regionArea><orgName type="university">Université de Mons</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Hainaut</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32816230</idno><idno type="pmid">32816230</idno><idno type="doi">10.1007/s12105-020-01212-5</idno><idno type="pmc">PMC7439628</idno><idno type="wicri:Area/Main/Corpus">000542</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000542</idno><idno type="wicri:Area/Main/Curation">000542</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000542</idno><idno type="wicri:Area/Main/Exploration">000542</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">ACE2 & TMPRSS2 Expressions in Head & Neck Tissues: A Systematic Review.</title><author><name sortKey="Lechien, Jerome R" sort="Lechien, Jerome R" uniqKey="Lechien J" first="Jerome R" last="Lechien">Jerome R. Lechien</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France. jerome.lechien@umons.ac.be.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium. jerome.lechien@umons.ac.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons</wicri:regionArea><orgName type="university">Université de Mons</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Hainaut</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Foch Hospital, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France. jerome.lechien@umons.ac.be.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Foch Hospital, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium. jerome.lechien@umons.ac.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Radulesco, Thomas" sort="Radulesco, Thomas" uniqKey="Radulesco T" first="Thomas" last="Radulesco">Thomas Radulesco</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception University Hospital, Aix Marseille Univ, APHM, IUSTI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception University Hospital, Aix Marseille Univ, APHM, IUSTI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Calvo Henriquez, Christian" sort="Calvo Henriquez, Christian" uniqKey="Calvo Henriquez C" first="Christian" last="Calvo-Henriquez">Christian Calvo-Henriquez</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology-Hospital Complex of Santiago de Compostela, Santiago de Compostela, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Otolaryngology-Hospital Complex of Santiago de Compostela, Santiago de Compostela</wicri:regionArea><wicri:noRegion>Santiago de Compostela</wicri:noRegion></affiliation></author><author><name sortKey="Chiesa Estomba, Carlos M" sort="Chiesa Estomba, Carlos M" uniqKey="Chiesa Estomba C" first="Carlos M" last="Chiesa-Estomba">Carlos M. Chiesa-Estomba</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology-Head & Neck Surgery, Hospital Universitario Donostia, San Sebastian, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Otorhinolaryngology-Head & Neck Surgery, Hospital Universitario Donostia, San Sebastian</wicri:regionArea><wicri:noRegion>San Sebastian</wicri:noRegion></affiliation></author><author><name sortKey="Hans, Stephane" sort="Hans, Stephane" uniqKey="Hans S" first="Stéphane" last="Hans">Stéphane Hans</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Foch Hospital, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Foch Hospital, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Barillari, Maria R" sort="Barillari, Maria R" uniqKey="Barillari M" first="Maria R" last="Barillari">Maria R. Barillari</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Mental and Physical Health and Preventive Medicine, University of L. Vanvitelli, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Mental and Physical Health and Preventive Medicine, University of L. Vanvitelli, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Cammaroto, Giovanni" sort="Cammaroto, Giovanni" uniqKey="Cammaroto G" first="Giovanni" last="Cammaroto">Giovanni Cammaroto</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology-Head & Neck Surgery, Morgagni Pierantoni Hospital, Forli, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Otolaryngology-Head & Neck Surgery, Morgagni Pierantoni Hospital, Forli</wicri:regionArea><wicri:noRegion>Forli</wicri:noRegion></affiliation></author><author><name sortKey="Descamps, Geraldine" sort="Descamps, Geraldine" uniqKey="Descamps G" first="Géraldine" last="Descamps">Géraldine Descamps</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons</wicri:regionArea><orgName type="university">Université de Mons</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Hainaut</region></placeName></affiliation></author><author><name sortKey="Hsieh, Julien" sort="Hsieh, Julien" uniqKey="Hsieh J" first="Julien" last="Hsieh">Julien Hsieh</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Rhinology-Olfactology Unit, Department of Otorhinolaryngology, Head and Neck Surgery, Geneva University Hospitals (HUG), Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Rhinology-Olfactology Unit, Department of Otorhinolaryngology, Head and Neck Surgery, Geneva University Hospitals (HUG), Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Vaira, Luigi" sort="Vaira, Luigi" uniqKey="Vaira L" first="Luigi" last="Vaira">Luigi Vaira</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Maxillofacial Surgery Unit, University Hospital of Sassari, Sassari, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Maxillofacial Surgery Unit, University Hospital of Sassari, Sassari</wicri:regionArea><wicri:noRegion>Sassari</wicri:noRegion></affiliation></author><author><name sortKey="De Riu, Giacomo" sort="De Riu, Giacomo" uniqKey="De Riu G" first="Giacomo" last="De Riu">Giacomo De Riu</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Maxillofacial Surgery Unit, University Hospital of Sassari, Sassari, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Maxillofacial Surgery Unit, University Hospital of Sassari, Sassari</wicri:regionArea><wicri:noRegion>Sassari</wicri:noRegion></affiliation></author><author><name sortKey="Sowerby, Leigh" sort="Sowerby, Leigh" uniqKey="Sowerby L" first="Leigh" last="Sowerby">Leigh Sowerby</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Gengler, Isabelle" sort="Gengler, Isabelle" uniqKey="Gengler I" first="Isabelle" last="Gengler">Isabelle Gengler</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati Medical Center, Cincinnati, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati Medical Center, Cincinnati, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Michel, Justin" sort="Michel, Justin" uniqKey="Michel J" first="Justin" last="Michel">Justin Michel</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception University Hospital, Aix Marseille Univ, APHM, IUSTI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception University Hospital, Aix Marseille Univ, APHM, IUSTI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Saussez, Sven" sort="Saussez, Sven" uniqKey="Saussez S" first="Sven" last="Saussez">Sven Saussez</name><affiliation wicri:level="3"><nlm:affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons</wicri:regionArea><orgName type="university">Université de Mons</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Hainaut</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author></analytic><series><title level="j">Head and neck pathology</title><idno type="eISSN">1936-0568</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To review the data regarding the expression of angiotensin converting enzyme-2 (ACE2) and transmembrane protease serine-2 (TMPRSS2) in head and neck tissue. Scopus, Cochrane Library, Medrxiv, Google Scholar and PubMED/MEDLINE were searched by four independent investigators for studies investigating ACE2 or TMPRSS2 expressions in head and neck tissues. The following outcomes were considered: sample origin (animal versus human); detection method; anatomical location and cell types. PRISMA checklist and modified population, intervention, comparison, outcome, timing and setting (PICOTS) framework were used to perform the review. Of the 24 identified studies, 17 met our inclusion criteria. Thirteen studies were conducted during the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic. ACE2 and TMPRSS2 were expressed in oral, pharyngeal, sinusonasal human mucosa. The following cell types expressed ACE2: basal, apical, goblet, minor salivary, and endothelial cells. TMPRSS2 was found in goblet and apical respiratory cells. ACE2 and TMPRSS2 were found in the olfactory region, especially in sustentacular non-neural and neural stem cells. Animal studies suggested that ACE2 expression may vary regarding age. There was an important heterogeneity between studies in the methods used to detect ACE2 and TMPRSS2, leading to a potential identification bias. The SARS-CoV-2 receptors, ACE2 and TMPRSS2, are both expressed in many head and neck tissues, enabling the viral entry into the host organism.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32816230</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1936-0568</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Aug</Month><Day>20</Day></PubDate></JournalIssue><Title>Head and neck pathology</Title><ISOAbbreviation>Head Neck Pathol</ISOAbbreviation></Journal><ArticleTitle>ACE2 & TMPRSS2 Expressions in Head & Neck Tissues: A Systematic Review.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1007/s12105-020-01212-5</ELocationID><Abstract><AbstractText>To review the data regarding the expression of angiotensin converting enzyme-2 (ACE2) and transmembrane protease serine-2 (TMPRSS2) in head and neck tissue. Scopus, Cochrane Library, Medrxiv, Google Scholar and PubMED/MEDLINE were searched by four independent investigators for studies investigating ACE2 or TMPRSS2 expressions in head and neck tissues. The following outcomes were considered: sample origin (animal versus human); detection method; anatomical location and cell types. PRISMA checklist and modified population, intervention, comparison, outcome, timing and setting (PICOTS) framework were used to perform the review. Of the 24 identified studies, 17 met our inclusion criteria. Thirteen studies were conducted during the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic. ACE2 and TMPRSS2 were expressed in oral, pharyngeal, sinusonasal human mucosa. The following cell types expressed ACE2: basal, apical, goblet, minor salivary, and endothelial cells. TMPRSS2 was found in goblet and apical respiratory cells. ACE2 and TMPRSS2 were found in the olfactory region, especially in sustentacular non-neural and neural stem cells. Animal studies suggested that ACE2 expression may vary regarding age. There was an important heterogeneity between studies in the methods used to detect ACE2 and TMPRSS2, leading to a potential identification bias. The SARS-CoV-2 receptors, ACE2 and TMPRSS2, are both expressed in many head and neck tissues, enabling the viral entry into the host organism.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lechien</LastName><ForeName>Jerome R</ForeName><Initials>JR</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-0845-0845</Identifier><AffiliationInfo><Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France. jerome.lechien@umons.ac.be.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium. jerome.lechien@umons.ac.be.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Foch Hospital, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France. jerome.lechien@umons.ac.be.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium. jerome.lechien@umons.ac.be.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Radulesco</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception University Hospital, Aix Marseille Univ, APHM, IUSTI, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Calvo-Henriquez</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otolaryngology-Hospital Complex of Santiago de Compostela, Santiago de Compostela, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chiesa-Estomba</LastName><ForeName>Carlos M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otorhinolaryngology-Head & Neck Surgery, Hospital Universitario Donostia, San Sebastian, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hans</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otolaryngology-Head & Neck Surgery, School of Medicine, Foch Hospital, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barillari</LastName><ForeName>Maria R</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Mental and Physical Health and Preventive Medicine, University of L. Vanvitelli, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cammaroto</LastName><ForeName>Giovanni</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otolaryngology-Head & Neck Surgery, Morgagni Pierantoni Hospital, Forli, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Descamps</LastName><ForeName>Géraldine</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hsieh</LastName><ForeName>Julien</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Rhinology-Olfactology Unit, Department of Otorhinolaryngology, Head and Neck Surgery, Geneva University Hospitals (HUG), Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vaira</LastName><ForeName>Luigi</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Maxillofacial Surgery Unit, University Hospital of Sassari, Sassari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Riu</LastName><ForeName>Giacomo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Maxillofacial Surgery Unit, University Hospital of Sassari, Sassari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sowerby</LastName><ForeName>Leigh</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gengler</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati Medical Center, Cincinnati, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Michel</LastName><ForeName>Justin</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception University Hospital, Aix Marseille Univ, APHM, IUSTI, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saussez</LastName><ForeName>Sven</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Head Neck Pathol</MedlineTA><NlmUniqueID>101304010</NlmUniqueID><ISSNLinking>1936-055X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">ACE2</Keyword><Keyword MajorTopicYN="N">COVID</Keyword><Keyword MajorTopicYN="N">Coronavirus</Keyword><Keyword MajorTopicYN="N">Head Neck</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">TMPRSS2</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>07</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>08</Month><Day>13</Day></PubMedPubDate><PubMedPubDate 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IdType="pubmed">11169526</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Belgique</li><li>Canada</li><li>Espagne</li><li>France</li><li>Italie</li><li>Suisse</li><li>États-Unis</li></country><region><li>Ohio</li><li>Provence-Alpes-Côte d'Azur</li><li>Province de Hainaut</li><li>Région de Bruxelles-Capitale</li><li>Région wallonne</li><li>Île-de-France</li></region><settlement><li>Bruxelles</li><li>Liège</li><li>Marseille</li><li>Paris</li></settlement><orgName><li>Université de Mons</li><li>Université libre de Bruxelles</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Lechien, Jerome R" sort="Lechien, Jerome R" uniqKey="Lechien J" first="Jerome R" last="Lechien">Jerome R. Lechien</name></region><name sortKey="Barillari, Maria R" sort="Barillari, Maria R" uniqKey="Barillari M" first="Maria R" last="Barillari">Maria R. Barillari</name><name sortKey="Calvo Henriquez, Christian" sort="Calvo Henriquez, Christian" uniqKey="Calvo Henriquez C" first="Christian" last="Calvo-Henriquez">Christian Calvo-Henriquez</name><name sortKey="Cammaroto, Giovanni" sort="Cammaroto, Giovanni" uniqKey="Cammaroto G" first="Giovanni" last="Cammaroto">Giovanni Cammaroto</name><name sortKey="Chiesa Estomba, Carlos M" sort="Chiesa Estomba, Carlos M" uniqKey="Chiesa Estomba C" first="Carlos M" last="Chiesa-Estomba">Carlos M. Chiesa-Estomba</name><name sortKey="De Riu, Giacomo" sort="De Riu, Giacomo" uniqKey="De Riu G" first="Giacomo" last="De Riu">Giacomo De Riu</name><name sortKey="Descamps, Geraldine" sort="Descamps, Geraldine" uniqKey="Descamps G" first="Géraldine" last="Descamps">Géraldine Descamps</name><name sortKey="Gengler, Isabelle" sort="Gengler, Isabelle" uniqKey="Gengler I" first="Isabelle" last="Gengler">Isabelle Gengler</name><name sortKey="Hans, Stephane" sort="Hans, Stephane" uniqKey="Hans S" first="Stéphane" last="Hans">Stéphane Hans</name><name sortKey="Hans, Stephane" sort="Hans, Stephane" uniqKey="Hans S" first="Stéphane" last="Hans">Stéphane Hans</name><name sortKey="Hsieh, Julien" sort="Hsieh, Julien" uniqKey="Hsieh J" first="Julien" last="Hsieh">Julien Hsieh</name><name sortKey="Lechien, Jerome R" sort="Lechien, Jerome R" uniqKey="Lechien J" first="Jerome R" last="Lechien">Jerome R. Lechien</name><name sortKey="Michel, Justin" sort="Michel, Justin" uniqKey="Michel J" first="Justin" last="Michel">Justin Michel</name><name sortKey="Michel, Justin" sort="Michel, Justin" uniqKey="Michel J" first="Justin" last="Michel">Justin Michel</name><name sortKey="Radulesco, Thomas" sort="Radulesco, Thomas" uniqKey="Radulesco T" first="Thomas" last="Radulesco">Thomas Radulesco</name><name sortKey="Radulesco, Thomas" sort="Radulesco, Thomas" uniqKey="Radulesco T" first="Thomas" last="Radulesco">Thomas Radulesco</name><name sortKey="Saussez, Sven" sort="Saussez, Sven" uniqKey="Saussez S" first="Sven" last="Saussez">Sven Saussez</name><name sortKey="Sowerby, Leigh" sort="Sowerby, Leigh" uniqKey="Sowerby L" first="Leigh" last="Sowerby">Leigh Sowerby</name><name sortKey="Vaira, Luigi" sort="Vaira, Luigi" uniqKey="Vaira L" first="Luigi" last="Vaira">Luigi Vaira</name></country><country name="Belgique"><region name="Région wallonne"><name sortKey="Lechien, Jerome R" sort="Lechien, Jerome R" uniqKey="Lechien J" first="Jerome R" last="Lechien">Jerome R. 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Chiesa-Estomba</name></country><country name="Italie"><noRegion><name sortKey="Barillari, Maria R" sort="Barillari, Maria R" uniqKey="Barillari M" first="Maria R" last="Barillari">Maria R. Barillari</name></noRegion><name sortKey="Cammaroto, Giovanni" sort="Cammaroto, Giovanni" uniqKey="Cammaroto G" first="Giovanni" last="Cammaroto">Giovanni Cammaroto</name><name sortKey="De Riu, Giacomo" sort="De Riu, Giacomo" uniqKey="De Riu G" first="Giacomo" last="De Riu">Giacomo De Riu</name><name sortKey="Vaira, Luigi" sort="Vaira, Luigi" uniqKey="Vaira L" first="Luigi" last="Vaira">Luigi Vaira</name></country><country name="Suisse"><noRegion><name sortKey="Hsieh, Julien" sort="Hsieh, Julien" uniqKey="Hsieh J" first="Julien" last="Hsieh">Julien Hsieh</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Sowerby, Leigh" sort="Sowerby, Leigh" uniqKey="Sowerby L" first="Leigh" last="Sowerby">Leigh Sowerby</name></noRegion></country><country name="États-Unis"><region name="Ohio"><name sortKey="Gengler, Isabelle" sort="Gengler, Isabelle" uniqKey="Gengler I" first="Isabelle" last="Gengler">Isabelle Gengler</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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